Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.
Sheldon: Why are you crying?
Penny: Because I’m stupid!
Sheldon: That’s no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.
Raj: I don’t like bugs, okay? They freak me out.
Sheldon: Interesting. You’re afraid of insects and women. Ladybugs must render you catatonic.
Sheldon: Stop it both of you! All this fighting, I might as well be back with my parents!
*Imitating his Mom* Dammit George! I told you if you didn’t quit drinking I would leave you!
*Imitating his Dad* Well, I guess that makes you a liar, because I’m drunk as hell and you are still here!
*Imitating his Mom* Stop yelling, you’re making Sheldon cry!
*Imitating his Dad* I’ll tell you what is making Sheldon cry, that I let you name him SHELDON!
Sheldon: I made tea.
Leonard: I don’t want tea.
Sheldon: I didn’t make tea for you. This is my tea.
Leonard: Then why are you telling me?
Sheldon: It’s a conversation starter.
Leonard: That’s a lousy conversation starter.
Sheldon: Oh, is it? We’re conversing. Checkmate.
Sheldon: I wouldn’t tell you the secret. (pause) Shhhhh!!!!
Leonard: What secret? Tell me the secret.
Sheldon: Mom smokes in the car. Jesus is okay with it, but we can’t tell dad.
Leonard: Not that secret, the other secret.
Sheldon: I’M BATMAN!!!! SHHHH!!!
Penny: So what do you say Sheldon, are we your X-men?
Sheldon: No, the X-men were named for the X in Charles Xavier. Since I am Sheldon Cooper, you will be, my C-men.
Sheldon: Ah, gravity – thou art a heartless bitch.
Sheldon: Your shoes are delightful. Where did you get them?
Sheldon: Bazinga, I don’t care.
Sheldon: At my age do you know how I’m statistically most likely to die?
Leonard: At the hands of your room mate?
Sheldon: An accident.
Leonard: That’s how I’m going to make it look.
Leonard: What were you doing at Penny’s?
Sheldon: Well, we had dinner, played some games, and then I spent the night. Oh, and you’ll be happy to know that I now have a much better understanding of ‘friends with benefits.’
Sheldon: You can try, but you’ll never catch me. Bazinga!
Zack: You know, I saw this great thing on the Discovery Channel. Turns out if you kill a starfish it’ll just come back to life.
Sheldon: Was the starfish wearing boxer shorts? Because you might have been watching Nickelodeon.
Sheldon: I think that you [Leonard] have as much of a chance of having a sexual relationship with Penny as the Hubble telescope does of discovering at the center of every black hole is a little man with a flashlight searching for a circuit breaker.
Penny: I always tear up when the Grinch’s heart grows three sizes.
Sheldon: Tears seem appropriate. Enlargement of the heart muscle, or hypertrophic cardiomyopathy, is a serious disease which can lead to congestive heart failure.
Amy Farrah Fowler: Did you know the iconic heart shape isn’t based on an actual human heart, its based on what a womans ass looks like bending over.
Penny: So in 8th grade, I was dotting my i’s with little asses? That’s cool.
Sheldon: This is the temperature you agreed to in the roommate agreement.
Leonard: Aw, screw the roommate agreement!
Sheldon: No, you don’t screw the roommate agreement. The roommate agreement screws you.
Sheldon: There there, everything is going to be fine… Sheldon’s here!